Comparative Genomics Reveals Accelerated Evolution in Conserved Pathways during the Diversification of Anole Lizards.

Squamates include all lizards and snakes, and display some of the most diverse and extreme morphological adaptations among vertebrates. However, compared with birds and mammals, relatively few resources exist for comparative genomic analyses of squamates, hampering efforts to understand the molecular bases of phenotypic diversification in such a speciose clade.

In particular, the ∼400 species of anolelizard represent an extensive squamate radiation. Here, we sequence and assemble the draft genomes of three anole species-Anolis frenatus, Anolis auratus, and Anolis apletophallus-for comparison with the available reference genome of Anolis carolinensis. Comparative analyses reveal a rapid background rate of molecular evolution consistent with a model of punctuated equilibrium, and strong purifying selection on functional genomic elements in anoles.

We find evidence for accelerated evolution in genes involved in behavior, sensory perception, and reproduction, as well as in genes regulating limb bud development and hindlimb specification. Morphometric analyses of anole fore and hindlimbs corroborated these findings.

SKT siRNA
20-abx933470	Abbexa	EUR 551.00 EUR 732.00	15 nmol 30 nmol
Shipped within 5-10 working days.

SKT (KIAA1217) Antibody
abx234542-100ug	Abbexa	100 ug	EUR 509
Shipped within 5-12 working days.

HSP70 ELISA Kit
SKT-105-480	Stressmarq	5 plates of 96 wells	EUR 2260
HSP70 genes encode abundant heat-inducible 70-kDa HSPs (HSP70s). In most eukaryotes HSP70 genes exist as part of a multigene family. They are found in most cellular compartments of eukaryotes including nuclei, mitochondria, chloroplasts, the endoplas Show more
Description: Sandwich ELISA kit used for quantitate HSP70 concentration in Cell Lysates, Tissue, Serum, Urine samples from Human, Goat, Dog

HSC70 ELISA Kit
SKT-106-480	Stressmarq	5 plates of 96 wells	EUR 2836
HSP70 genes encode abundant heat-inducible 70-kDa HSPs (HSP70s). In most eukaryotes HSP70 genes exist as part of a multigene family. They are found in most cellular compartments of eukaryotes including nuclei, mitochondria, chloroplasts, the endoplas Show more
Description: Sandwich ELISA kit used for quantitate HSC70 concentration in Cell Lysates, Tissue, Serum, Whole Blood samples from Human, Avian

HSP90 alpha ELISA Kit
SKT-107-480	Stressmarq	5 plates of 96 wells	EUR 2702
HSP90 is a highly conserved and essential stress protein that is expressed in all eukaryotic cells. From a functional perspective, HSP90 participates in the folding, assembly, maturation, and stabilization of specific proteins as an integral componen Show more
Description: Sandwich ELISA kit used for quantitate HSP90 alpha concentration in Cell Lysates, Tissue, Serum, Whole Blood samples from Human, Goat, Avian

HSP70 ELISA Kit (High-Sensitivity)
SKT-108-480	Stressmarq	5 plates of 96 wells	EUR 2702
HSP70 genes encode abundant heat-inducible 70-kDa HSPs (HSP70s). In most eukaryotes HSP70 genes exist as part of a multigene family. They are found in most cellular compartments of eukaryotes including nuclei, mitochondria, chloroplasts, the endoplas Show more
Description: Sandwich ELISA kit used for quantitate HSP70 concentration in Serum, Plasma, Cell Lysates, Tissue samples from Human, Monkey, Dog, Rat, Mouse

HSP27 ELISA Kit
SKT-109-480	Stressmarq	5 plates of 96 wells	EUR 2277
HSP27s belong to an abundant and ubiquitous family of small heat shock proteins (sHSP). It is an important HSP found in both normal human cells and cancer cells. The basic structure of most sHSPs is a homologous and highly conserved amino acid sequen Show more
Description: Sandwich ELISA kit used for quantitate HSP27 concentration in Serum, Plasma, Cell Lysates, Tissue samples from Human

HSP60 ELISA Kit
SKT-110-480	Stressmarq	5 plates of 96 wells	EUR 2277
In both prokaryotic and eukaryotic cells, the misfolding and aggregation of proteins during biogenesis and under conditions of cellular stress are prevented by molecular chaperones. Members of the HSP60 family of heat shock proteins are some of the b Show more
Description: Sandwich ELISA kit used for quantitate HSP60 concentration in Cell Lysates, Tissue, Serum samples from Human

HSP65 ELISA Kit
SKT-113-480	Stressmarq	5 plates of 96 wells	EUR 2478
HSP65 is a member of the HSP60 family of heat shock proteins (2, 3). HSP60s are mitochondrial chaperonins that are typically held responsible for the transportation and refolding of proteins from the cytoplasm into the mitochondrial matrix. In additi Show more
Description: Sandwich ELISA kit used for quantitate M bovis/M tuberculosum HSP65 concentration in human samples in Cell Lysates, Tissue, Serum samples from M bovis, M tuberculosum

Alpha B Crystallin ELISA Kit
SKT-123-480	Stressmarq	5 plates of 96 wells	EUR 2836
The alpha-crystallins are major water-soluble lens structural proteins of the vertebrate eye that are related to the small heat shock protein family. The alpha-crystallins possess structural and functional similarities with HSP25 and HSP27 (1). Mamma Show more
Description: Sandwich ELISA kit used for quantitate alpha B crystallin concentration in Cell Lysates, Tissue, Serum samples from Human

HSP70 ELISA Kit (PLANT)
SKT-124-480	Stressmarq	5 plates of 96 wells	EUR 2836
HSP70 genes encode abundant heat-inducible 70-kDa HSPs (HSP70s). In most eukaryotes HSP70 genes exist as part of a multigene family. They are found in most cellular compartments of eukaryotes including nuclei, mitochondria, chloroplasts, the endoplas Show more
Description: Sandwich ELISA kit used for quantitate HSP70 concentration in Plant extract, Cell Lysates, Tissue, Serum, Plasma samples from Plant, Human

Nitrotyrosine ELISA Kit
SKT-126-480	Stressmarq	5 plates of 96 wells	EUR 1747
Nitrotyrosine has been identified as a marker of inflammation and NO production. Nitrotyrosine is formed in presence of the active metabolite NO. Various pathways including the formation of peroxinitrite lead to nitrotyrosine production. Since nitrot Show more
Description: Competitive ELISA kit used for quantitate Nitrotyrosine in Plasma, Serum, Cell Lysates, Urine samples from all species

Rat GRP78 ELISA Kit
SKT-137-480	Stressmarq	5 plates of 96 wells	EUR 2474
GRP78 is a ubiquitously expressed, 78-kDa glucose-regulated protein, and is commonly referred to as an immunoglobin chain binding protein (BiP). The BiP proteins are categorized as stress response proteins because they play an important role in the p Show more
Description: Sandwich ELISA kit used for quantitate GRP78 concentration in rat samples in Tissue samples from Rat

Dibromo-tyrosine ELISA Kit
SKT-140-480	Stressmarq	5 plates of 96 wells	EUR 2195
Dibromo-tyrosine is produced by the oxidative bromination of tyrosine residues. This reaction occurs via eosinophil peroxidase (EPO), an enzyme released by activated eosinophils. Upon activation of eosinophils, a respiratory burst occurs releasing el Show more
Description: Competitive ELISA kit used to quantify free and protein-bound 3,5-dibromotyrosine in Plasma, Urine samples from all species

HO-1 ELISA Kit
SKT-111-96	Stressmarq	1 plate of 96 wells	EUR 585
Heme-oxygenase is a ubiquitous enzyme that catalyzes the initial and rate-limiting steps in heme catabolism yielding equimolar amounts of biliverdin, iron and carbon monoxide. Biliverdin is subsequently converted to bilirubin and the free iron is seq Show more
Description: Sandwich ELISA kit used for quantitate HO-1 concentration in Cell Lysates, Tissue, Serum, Cyst fluid samples from Human, Rat

Mouse SKT shRNA Plasmid
20-abx980555	Abbexa	EUR 801.00 EUR 1121.00	150 µg 300 µg
Shipped within 15-20 working days.

JW 480
B5556-10	ApexBio	10 mg	EUR 167

JW 480
B5556-25	ApexBio	25 mg	EUR 325

JW 480
B5556-5	ApexBio	5 mg	EUR 110

JW 480
B5556-50	ApexBio	50 mg	EUR 540

Sulforhodamine 101 sulfonyl chloride [Texas Red®] *CAS 82354-19-6*
480	AAT Bioquest	10 mg	EUR 132
R-phrase: R20, R21, R22 H-Phrase: H303, H313, H333 Symbol for dangerous compounds: Xn UNSPEC Code: 12171501

Superior Prime Broth™
111	AthenaES	500 g	EUR 110

Mouse Sickle tail protein, Skt ELISA KIT
ELI-29595m	Lifescience Market	96 Tests	EUR 865

Mouse Sickle tail protein (SKT) ELISA Kit
abx389166-96tests	Abbexa	96 tests	EUR 911
Shipped within 5-12 working days.

Laminin 111
RA22121	Neuromics	100 ul	EUR 435

Human Sickle tail protein homolog, SKT ELISA KIT
ELI-18163h	Lifescience Market	96 Tests	EUR 824

Handheld Fluorometer 480/530nm
FL480530	BioAssay Systems	1 unit	EUR 1572
Description: Compact handheld fluorometer (exc.480 and em.530nm) for quantitative determination of various analytes in life sciences R&D, food safety and environmental monitoring. Highly sensitive, rapid-reading, reliable and low cost.

Skt ELISA Kit| Mouse Sickle tail protein ELISA Kit
EF014796	Lifescience Market	96 Tests	EUR 689

Polyclonal ADD3 Antibody (aa431-480)
APR14821G	Leading Biology	0.05ml	EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human ADD3 (aa431-480). This antibody is tested and proven to work in the following applications:

Anti-DDX41 (aa468-480) antibody
STJ73402	St John's Laboratory	100 µg	EUR 359

CD45RA(111-1C5) Antibody
BNUM1038-50	Biotium	50uL	EUR 395
Description: Primary antibody against CD45RA(111-1C5), 1mg/mL

CD45RA(111-1C5) Antibody
BNUB1038-100	Biotium	100uL	EUR 209
Description: Primary antibody against CD45RA(111-1C5), Concentration: 0.2mg/mL

CD45RA(111-1C5) Antibody
BNUB1038-500	Biotium	500uL	EUR 458
Description: Primary antibody against CD45RA(111-1C5), Concentration: 0.2mg/mL

CD45RA(111-1C5) Antibody
BNC551038-100	Biotium	100uL	EUR 199
Description: Primary antibody against CD45RA(111-1C5), CF555 conjugate, Concentration: 0.1mg/mL

CD45RA(111-1C5) Antibody
BNC551038-500	Biotium	500uL	EUR 544
Description: Primary antibody against CD45RA(111-1C5), CF555 conjugate, Concentration: 0.1mg/mL

CD45RA(111-1C5) Antibody
BNC611038-100	Biotium	100uL	EUR 199
Description: Primary antibody against CD45RA(111-1C5), CF660R conjugate, Concentration: 0.1mg/mL

CD45RA(111-1C5) Antibody
BNC611038-500	Biotium	500uL	EUR 544
Description: Primary antibody against CD45RA(111-1C5), CF660R conjugate, Concentration: 0.1mg/mL

CD45RA(111-1C5) Antibody
BNC471038-100	Biotium	100uL	EUR 199
Description: Primary antibody against CD45RA(111-1C5), CF647 conjugate, Concentration: 0.1mg/mL

CD45RA(111-1C5) Antibody
BNC471038-500	Biotium	500uL	EUR 544
Description: Primary antibody against CD45RA(111-1C5), CF647 conjugate, Concentration: 0.1mg/mL

CD45RA(111-1C5) Antibody
BNC051038-100	Biotium	100uL	EUR 199
Description: Primary antibody against CD45RA(111-1C5), CF405M conjugate, Concentration: 0.1mg/mL

CD45RA(111-1C5) Antibody
BNC051038-500	Biotium	500uL	EUR 544
Description: Primary antibody against CD45RA(111-1C5), CF405M conjugate, Concentration: 0.1mg/mL

CD45RA(111-1C5) Antibody
BNC401038-100	Biotium	100uL	EUR 199
Description: Primary antibody against CD45RA(111-1C5), CF640R conjugate, Concentration: 0.1mg/mL

CD45RA(111-1C5) Antibody
BNC401038-500	Biotium	500uL	EUR 544
Description: Primary antibody against CD45RA(111-1C5), CF640R conjugate, Concentration: 0.1mg/mL

CD45RA(111-1C5) Antibody
BNC431038-100	Biotium	100uL	EUR 199
Description: Primary antibody against CD45RA(111-1C5), CF543 conjugate, Concentration: 0.1mg/mL

CD45RA(111-1C5) Antibody
BNC431038-500	Biotium	500uL	EUR 544
Description: Primary antibody against CD45RA(111-1C5), CF543 conjugate, Concentration: 0.1mg/mL

CD45RA(111-1C5) Antibody
BNC041038-100	Biotium	100uL	EUR 199
Description: Primary antibody against CD45RA(111-1C5), CF405S conjugate, Concentration: 0.1mg/mL

CD45RA(111-1C5) Antibody
BNC041038-500	Biotium	500uL	EUR 544
Description: Primary antibody against CD45RA(111-1C5), CF405S conjugate, Concentration: 0.1mg/mL

CD45RA(111-1C5) Antibody
BNC801038-100	Biotium	100uL	EUR 199
Description: Primary antibody against CD45RA(111-1C5), CF680 conjugate, Concentration: 0.1mg/mL

CD45RA(111-1C5) Antibody
BNC801038-500	Biotium	500uL	EUR 544
Description: Primary antibody against CD45RA(111-1C5), CF680 conjugate, Concentration: 0.1mg/mL

CD45RA(111-1C5) Antibody
BNCP1038-250	Biotium	250uL	EUR 383
Description: Primary antibody against CD45RA(111-1C5), PerCP conjugate, Concentration: 0.1mg/mL

CD45RA(111-1C5) Antibody
BNCR1038-250	Biotium	250uL	EUR 383
Description: Primary antibody against CD45RA(111-1C5), RPE conjugate, Concentration: 0.1mg/mL

CD45RA(111-1C5) Antibody
BNCA1038-250	Biotium	250uL	EUR 383
Description: Primary antibody against CD45RA(111-1C5), APC conjugate, Concentration: 0.1mg/mL

CD45RA(111-1C5) Antibody
BNCAP1038-100	Biotium	100uL	EUR 199
Description: Primary antibody against CD45RA(111-1C5), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

CD45RA(111-1C5) Antibody
BNCAP1038-500	Biotium	500uL	EUR 544
Description: Primary antibody against CD45RA(111-1C5), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

CD45RA(111-1C5) Antibody
BNCB1038-100	Biotium	100uL	EUR 199
Description: Primary antibody against CD45RA(111-1C5), Biotin conjugate, Concentration: 0.1mg/mL

CD45RA(111-1C5) Antibody
BNCB1038-500	Biotium	500uL	EUR 544
Description: Primary antibody against CD45RA(111-1C5), Biotin conjugate, Concentration: 0.1mg/mL

CD45RA(111-1C5) Antibody
BNCH1038-100	Biotium	100uL	EUR 199
Description: Primary antibody against CD45RA(111-1C5), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL

CD45RA(111-1C5) Antibody
BNCH1038-500	Biotium	500uL	EUR 544
Description: Primary antibody against CD45RA(111-1C5), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL

CD45RA(111-1C5) Antibody
BNC881038-100	Biotium	100uL	EUR 199
Description: Primary antibody against CD45RA(111-1C5), CF488A conjugate, Concentration: 0.1mg/mL

CD45RA(111-1C5) Antibody
BNC881038-500	Biotium	500uL	EUR 544
Description: Primary antibody against CD45RA(111-1C5), CF488A conjugate, Concentration: 0.1mg/mL

CD45RA(111-1C5) Antibody
BNC941038-100	Biotium	100uL	EUR 199
Description: Primary antibody against CD45RA(111-1C5), CF594 conjugate, Concentration: 0.1mg/mL

CD45RA(111-1C5) Antibody
BNC941038-500	Biotium	500uL	EUR 544
Description: Primary antibody against CD45RA(111-1C5), CF594 conjugate, Concentration: 0.1mg/mL

CD45RA(111-1C5) Antibody
BNC681038-100	Biotium	100uL	EUR 199
Description: Primary antibody against CD45RA(111-1C5), CF568 conjugate, Concentration: 0.1mg/mL

CD45RA(111-1C5) Antibody
BNC681038-500	Biotium	500uL	EUR 544
Description: Primary antibody against CD45RA(111-1C5), CF568 conjugate, Concentration: 0.1mg/mL

CD45RA(111-1C5) Antibody
BNC701038-100	Biotium	100uL	EUR 199
Description: Primary antibody against CD45RA(111-1C5), CF770 conjugate, Concentration: 0.1mg/mL

CD45RA(111-1C5) Antibody
BNC701038-500	Biotium	500uL	EUR 544
Description: Primary antibody against CD45RA(111-1C5), CF770 conjugate, Concentration: 0.1mg/mL

CD45RA(111-1C5) Antibody
BNC811038-100	Biotium	100uL	EUR 199
Description: Primary antibody against CD45RA(111-1C5), CF680R conjugate, Concentration: 0.1mg/mL

CD45RA(111-1C5) Antibody
BNC811038-500	Biotium	500uL	EUR 544
Description: Primary antibody against CD45RA(111-1C5), CF680R conjugate, Concentration: 0.1mg/mL

pOTB7-CLDN5(111-912bp)
PVT18531	Lifescience Market	2 ug	EUR 231

SSEA-1 Antibody (Clone MC-480)
3063-25	Biovision		EUR 272

Polyclonal TAOK1 / TAO1 Antibody (aa431-480)
AMM08087G	Leading Biology	0.05ml	EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human TAOK1 / TAO1 (aa431-480). This antibody is tested and proven to work in the following applications:

Zinc Finger Protein 480 (ZNF480) Antibody
20-abx116741	Abbexa	EUR 732.00 EUR 398.00	150 ul 50 ul
Shipped within 5-10 working days.

Zinc Finger Protein 480 (ZNF480) Antibody
abx030192-400ul	Abbexa	400 ul	EUR 523
Shipped within 5-10 working days.

Zinc Finger Protein 480 (ZNF480) Antibody
abx030192-80l	Abbexa	80 µl	EUR 286
Shipped within 5-10 working days.

Myosin Light Chain Kinase (480-501)
H-3554.0500	Bachem	0.5mg	EUR 273
Description: Sum Formula: C120H209N41O28S2; CAS# [313642-00-1]

Myosin Light Chain Kinase (480-501)
H-3554.1000	Bachem	1.0mg	EUR 466
Description: Sum Formula: C120H209N41O28S2; CAS# [313642-00-1]

Monoclonal CGA / hCG Alpha Antibody (clone ME.111), Clone: ME.111
APG02560G	Leading Biology	0.1mg	EUR 484
Description: A Monoclonal antibody against Human CGA / hCG Alpha (clone ME.111). The antibodies are raised in Mouse and are from clone ME.111. This antibody is applicable in WB and IHC-P, E

WST-1 Cell Proliferation Colorimetric Assay Kit
K2021-480	ApexBio	480 assays	EUR 321

amfiSure PCR Premix, 8-Strip 0.2ml tube with Individual attached cap
P0316-480	GenDepot	5X96 rxns	EUR 529

amfiEco PCR Premix
P0702-480	GenDepot	5x96 rxns	EUR 444

amfiRivert 1-Step RT-PCR Premix
R5004-480	GenDepot	5x96 rxns	EUR 928

Recombinant (E.Coli, GST tag) Hepatitis C Virus (HCV) NS5 Genotype-4
RP-480	Alpha Diagnostics	100 ug	EUR 286

Prepro VIP (111-122) (human)
5-01793	CHI Scientific	4 x 5mg	Ask for price

Transmembrane Protein 111 (TM111) Antibody
abx032614-400ul	Abbexa	400 ul	EUR 523
Shipped within 5-10 working days.

Transmembrane Protein 111 (TM111) Antibody
abx032614-80l	Abbexa	80 µl	EUR 286
Shipped within 5-10 working days.

Prepro VIP (111-122) Peptide
20-abx265194	Abbexa	EUR 495.00 EUR 815.00 EUR 356.00	10 mg 25 mg 5 mg
Shipped within 5-10 working days.

Recombinant ASFV Ken-111 Protein
VAng-2105Lsx-inquire	Creative Biolabs	inquire	Ask for price
Description: African swine fever virus (isolate Pig/Kenya/KEN-50/1950) Probable DNA-directed RNA polymerase subunit 1 homolog (Ken-111), partial, recombinant protein from E. coli. (Uniprot ID: P0C989)

Recombinant ASFV Pret-111 Protein
VAng-2401Lsx-inquire	Creative Biolabs	inquire	Ask for price
Description: African swine fever virus (isolate Tick/South Africa/Pretoriuskop Pr4/1996) Probable DNA-directed RNA polymerase subunit 1 homolog (Pret-111), partial, recombinant protein from E. coli. (Uniprot ID: P0C987)

Recombinant ASFV War-111 Protein
VAng-2507Lsx-inquire	Creative Biolabs	inquire	Ask for price
Description: African swine fever virus (isolate Warthog/Namibia/Wart80/1980) Probable mRNA-capping enzyme (War-111), partial, recombinant protein from E. coli. (Uniprot ID: P0C994)

Anti-PCDH17 (aa1098-111) antibody
STJ72707	St John's Laboratory	100 µg	EUR 359

Protein-A ELISA Kit, 480 tests, Quantitative
800-110-PRA-5	Alpha Diagnostics	1 pk	EUR 3095

Mouse Olfactory receptor 480, Olfr480 ELISA KIT
ELI-14769m	Lifescience Market	96 Tests	EUR 865

Opti-Seal qPCR Roche 480 (Low profile)
G913	ABM	100 Plates/Case	EUR 302

Opti-Seal qPCR Roche 480 (Low profile)
G914	ABM	10 Plates/Box	EUR 76

Recombinant MARV nifE (aa 1-480) Protein
VAng-Wyb3541-1mgEcoli	Creative Biolabs	1 mg (E. coli)	EUR 5247
Description: Methanothermobacter marburgensis (strain DSM 2133 / 14651 / NBRC 100331 / OCM 82 / Marburg) nitrogenase iron-molybdenum cofactor biosynthesis protein NifE, recombinant protein.

Recombinant MARV nifE (aa 1-480) Protein
VAng-Wyb3541-500gEcoli	Creative Biolabs	500 µg (E. coli)	EUR 3707
Description: Methanothermobacter marburgensis (strain DSM 2133 / 14651 / NBRC 100331 / OCM 82 / Marburg) nitrogenase iron-molybdenum cofactor biosynthesis protein NifE, recombinant protein.

Recombinant MARV nifE (aa 1-480) Protein
VAng-Wyb3541-50gEcoli	Creative Biolabs	50 µg (E. coli)	EUR 2525
Description: Methanothermobacter marburgensis (strain DSM 2133 / 14651 / NBRC 100331 / OCM 82 / Marburg) nitrogenase iron-molybdenum cofactor biosynthesis protein NifE, recombinant protein.

Recombinant Rat Akt1 Protein (aa 1-480)
VAng-2932Lsx-1mg	Creative Biolabs	1 mg	EUR 5590
Description: Recombinant Rat Akt1 is expressed in E. coli. (Uniprot ID: P47196)

We detect signatures of positive selection across several genes related to the development and regulation of the forebrain, hormones, and the iguanian lizard dewlap, suggesting molecular changes underlying behavioral adaptations known to reinforce species boundaries were a key component in the diversification of anolelizards.