Comparative Genomics Reveals Accelerated Evolution in Conserved Pathways during the Diversification of Anole Lizards.

Squamates include all lizards and snakes, and display some of the most diverse and extreme morphological adaptations among vertebrates. However, compared with birds and mammals, relatively few resources exist for comparative genomic analyses of squamates, hampering efforts to understand the molecular bases of phenotypic diversification in such a speciose clade.

In particular, the ∼400 species of anolelizard represent an extensive squamate radiation. Here, we sequence and assemble the draft genomes of three anole species-Anolis frenatus, Anolis auratus, and Anolis apletophallus-for comparison with the available reference genome of Anolis carolinensis. Comparative analyses reveal a rapid background rate of molecular evolution consistent with a model of punctuated equilibrium, and strong purifying selection on functional genomic elements in anoles.

We find evidence for accelerated evolution in genes involved in behavior, sensory perception, and reproduction, as well as in genes regulating limb bud development and hindlimb specification. Morphometric analyses of anole fore and hindlimbs corroborated these findings.

HSP70 ELISA Kit

SKT-105-480 5 plates of 96 wells
EUR 2260
Description: Sandwich ELISA kit used for quantitate HSP70 concentration in Cell Lysates, Tissue, Serum, Urine samples from Human, Goat, Dog

HSC70 ELISA Kit

SKT-106-480 5 plates of 96 wells
EUR 2836
Description: Sandwich ELISA kit used for quantitate HSC70 concentration in Cell Lysates, Tissue, Serum, Whole Blood samples from Human, Avian

HSP90 alpha ELISA Kit

SKT-107-480 5 plates of 96 wells
EUR 2702
Description: Sandwich ELISA kit used for quantitate HSP90 alpha concentration in Cell Lysates, Tissue, Serum, Whole Blood samples from Human, Goat, Avian

HSP70 ELISA Kit (High-Sensitivity)

SKT-108-480 5 plates of 96 wells
EUR 2702
Description: Sandwich ELISA kit used for quantitate HSP70 concentration in Serum, Plasma, Cell Lysates, Tissue samples from Human, Monkey, Dog, Rat, Mouse

HSP27 ELISA Kit

SKT-109-480 5 plates of 96 wells
EUR 2277
Description: Sandwich ELISA kit used for quantitate HSP27 concentration in Serum, Plasma, Cell Lysates, Tissue samples from Human

HSP60 ELISA Kit

SKT-110-480 5 plates of 96 wells
EUR 2277
Description: Sandwich ELISA kit used for quantitate HSP60 concentration in Cell Lysates, Tissue, Serum samples from Human

HSP65 ELISA Kit

SKT-113-480 5 plates of 96 wells
EUR 2478
Description: Sandwich ELISA kit used for quantitate M bovis/M tuberculosum HSP65 concentration in human samples in Cell Lysates, Tissue, Serum samples from M bovis, M tuberculosum

Alpha B Crystallin ELISA Kit

SKT-123-480 5 plates of 96 wells
EUR 2836
Description: Sandwich ELISA kit used for quantitate alpha B crystallin concentration in Cell Lysates, Tissue, Serum samples from Human

HSP70 ELISA Kit (PLANT)

SKT-124-480 5 plates of 96 wells
EUR 2836
Description: Sandwich ELISA kit used for quantitate HSP70 concentration in Plant extract, Cell Lysates, Tissue, Serum, Plasma samples from Plant, Human

Nitrotyrosine ELISA Kit

SKT-126-480 5 plates of 96 wells
EUR 1747
Description: Competitive ELISA kit used for quantitate Nitrotyrosine in Plasma, Serum, Cell Lysates, Urine samples from all species

Rat GRP78 ELISA Kit

SKT-137-480 5 plates of 96 wells
EUR 2474
Description: Sandwich ELISA kit used for quantitate GRP78 concentration in rat samples in Tissue samples from Rat

Dibromo-tyrosine ELISA Kit

SKT-140-480 5 plates of 96 wells
EUR 2195
Description: Competitive ELISA kit used to quantify free and protein-bound 3,5-dibromotyrosine in Plasma, Urine samples from all species

HO-1 ELISA Kit

SKT-111-96 1 plate of 96 wells
EUR 585
Description: Sandwich ELISA kit used for quantitate HO-1 concentration in Cell Lysates, Tissue, Serum, Cyst fluid samples from Human, Rat

Mouse SKT shRNA Plasmid

20-abx980555
  • EUR 801.00
  • EUR 1121.00
  • 150 µg
  • 300 µg

JW 480

B5556-10 10 mg
EUR 167

JW 480

B5556-25 25 mg
EUR 325

JW 480

B5556-5 5 mg
EUR 110

JW 480

B5556-50 50 mg
EUR 540

Sulforhodamine 101 sulfonyl chloride [Texas Red®] *CAS 82354-19-6*

480 10 mg
EUR 132

Mouse Sickle tail protein (SKT) ELISA Kit

abx389166-96tests 96 tests
EUR 911

Mouse Sickle tail protein, Skt ELISA KIT

ELI-29595m 96 Tests
EUR 865

Laminin 111

RA22121 100 ul
EUR 435

Superior Prime Broth™

111 500 g
EUR 110

Human Sickle tail protein homolog, SKT ELISA KIT

ELI-18163h 96 Tests
EUR 824

Handheld Fluorometer 480/530nm

FL480530 1 unit
EUR 1572
Description: Compact handheld fluorometer (exc.480 and em.530nm) for quantitative determination of various analytes in life sciences R&D, food safety and environmental monitoring. Highly sensitive, rapid-reading, reliable and low cost.

Skt ELISA Kit| Mouse Sickle tail protein ELISA Kit

EF014796 96 Tests
EUR 689

Anti-DDX41 (aa468-480) antibody

STJ73402 100 µg
EUR 359

Polyclonal ADD3 Antibody (aa431-480)

APR14821G 0.05ml
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human ADD3 (aa431-480). This antibody is tested and proven to work in the following applications:

CD45RA(111-1C5) Antibody

BNCA1038-250 250uL
EUR 383
Description: Primary antibody against CD45RA(111-1C5), APC conjugate, Concentration: 0.1mg/mL

CD45RA(111-1C5) Antibody

BNC811038-100 100uL
EUR 199
Description: Primary antibody against CD45RA(111-1C5), CF680R conjugate, Concentration: 0.1mg/mL

CD45RA(111-1C5) Antibody

BNC811038-500 500uL
EUR 544
Description: Primary antibody against CD45RA(111-1C5), CF680R conjugate, Concentration: 0.1mg/mL

CD45RA(111-1C5) Antibody

BNCAP1038-100 100uL
EUR 199
Description: Primary antibody against CD45RA(111-1C5), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

CD45RA(111-1C5) Antibody

BNCAP1038-500 500uL
EUR 544
Description: Primary antibody against CD45RA(111-1C5), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

CD45RA(111-1C5) Antibody

BNCB1038-100 100uL
EUR 199
Description: Primary antibody against CD45RA(111-1C5), Biotin conjugate, Concentration: 0.1mg/mL

CD45RA(111-1C5) Antibody

BNCB1038-500 500uL
EUR 544
Description: Primary antibody against CD45RA(111-1C5), Biotin conjugate, Concentration: 0.1mg/mL

CD45RA(111-1C5) Antibody

BNC471038-100 100uL
EUR 199
Description: Primary antibody against CD45RA(111-1C5), CF647 conjugate, Concentration: 0.1mg/mL

CD45RA(111-1C5) Antibody

BNC471038-500 500uL
EUR 544
Description: Primary antibody against CD45RA(111-1C5), CF647 conjugate, Concentration: 0.1mg/mL

CD45RA(111-1C5) Antibody

BNC551038-100 100uL
EUR 199
Description: Primary antibody against CD45RA(111-1C5), CF555 conjugate, Concentration: 0.1mg/mL

CD45RA(111-1C5) Antibody

BNC551038-500 500uL
EUR 544
Description: Primary antibody against CD45RA(111-1C5), CF555 conjugate, Concentration: 0.1mg/mL

CD45RA(111-1C5) Antibody

BNC431038-100 100uL
EUR 199
Description: Primary antibody against CD45RA(111-1C5), CF543 conjugate, Concentration: 0.1mg/mL

CD45RA(111-1C5) Antibody

BNC431038-500 500uL
EUR 544
Description: Primary antibody against CD45RA(111-1C5), CF543 conjugate, Concentration: 0.1mg/mL

CD45RA(111-1C5) Antibody

BNC881038-100 100uL
EUR 199
Description: Primary antibody against CD45RA(111-1C5), CF488A conjugate, Concentration: 0.1mg/mL

CD45RA(111-1C5) Antibody

BNC881038-500 500uL
EUR 544
Description: Primary antibody against CD45RA(111-1C5), CF488A conjugate, Concentration: 0.1mg/mL

CD45RA(111-1C5) Antibody

BNC941038-100 100uL
EUR 199
Description: Primary antibody against CD45RA(111-1C5), CF594 conjugate, Concentration: 0.1mg/mL

CD45RA(111-1C5) Antibody

BNC941038-500 500uL
EUR 544
Description: Primary antibody against CD45RA(111-1C5), CF594 conjugate, Concentration: 0.1mg/mL

CD45RA(111-1C5) Antibody

BNCP1038-250 250uL
EUR 383
Description: Primary antibody against CD45RA(111-1C5), PerCP conjugate, Concentration: 0.1mg/mL

CD45RA(111-1C5) Antibody

BNC041038-100 100uL
EUR 199
Description: Primary antibody against CD45RA(111-1C5), CF405S conjugate, Concentration: 0.1mg/mL

CD45RA(111-1C5) Antibody

BNC041038-500 500uL
EUR 544
Description: Primary antibody against CD45RA(111-1C5), CF405S conjugate, Concentration: 0.1mg/mL

CD45RA(111-1C5) Antibody

BNC051038-100 100uL
EUR 199
Description: Primary antibody against CD45RA(111-1C5), CF405M conjugate, Concentration: 0.1mg/mL

CD45RA(111-1C5) Antibody

BNC051038-500 500uL
EUR 544
Description: Primary antibody against CD45RA(111-1C5), CF405M conjugate, Concentration: 0.1mg/mL

CD45RA(111-1C5) Antibody

BNCR1038-250 250uL
EUR 383
Description: Primary antibody against CD45RA(111-1C5), RPE conjugate, Concentration: 0.1mg/mL

CD45RA(111-1C5) Antibody

BNUB1038-100 100uL
EUR 209
Description: Primary antibody against CD45RA(111-1C5), Concentration: 0.2mg/mL

CD45RA(111-1C5) Antibody

BNUB1038-500 500uL
EUR 458
Description: Primary antibody against CD45RA(111-1C5), Concentration: 0.2mg/mL

CD45RA(111-1C5) Antibody

BNC681038-100 100uL
EUR 199
Description: Primary antibody against CD45RA(111-1C5), CF568 conjugate, Concentration: 0.1mg/mL

CD45RA(111-1C5) Antibody

BNC681038-500 500uL
EUR 544
Description: Primary antibody against CD45RA(111-1C5), CF568 conjugate, Concentration: 0.1mg/mL

CD45RA(111-1C5) Antibody

BNC701038-100 100uL
EUR 199
Description: Primary antibody against CD45RA(111-1C5), CF770 conjugate, Concentration: 0.1mg/mL

CD45RA(111-1C5) Antibody

BNC701038-500 500uL
EUR 544
Description: Primary antibody against CD45RA(111-1C5), CF770 conjugate, Concentration: 0.1mg/mL

CD45RA(111-1C5) Antibody

BNC611038-100 100uL
EUR 199
Description: Primary antibody against CD45RA(111-1C5), CF660R conjugate, Concentration: 0.1mg/mL

CD45RA(111-1C5) Antibody

BNC611038-500 500uL
EUR 544
Description: Primary antibody against CD45RA(111-1C5), CF660R conjugate, Concentration: 0.1mg/mL

CD45RA(111-1C5) Antibody

BNC401038-100 100uL
EUR 199
Description: Primary antibody against CD45RA(111-1C5), CF640R conjugate, Concentration: 0.1mg/mL

CD45RA(111-1C5) Antibody

BNC401038-500 500uL
EUR 544
Description: Primary antibody against CD45RA(111-1C5), CF640R conjugate, Concentration: 0.1mg/mL

CD45RA(111-1C5) Antibody

BNC801038-100 100uL
EUR 199
Description: Primary antibody against CD45RA(111-1C5), CF680 conjugate, Concentration: 0.1mg/mL

CD45RA(111-1C5) Antibody

BNC801038-500 500uL
EUR 544
Description: Primary antibody against CD45RA(111-1C5), CF680 conjugate, Concentration: 0.1mg/mL

CD45RA(111-1C5) Antibody

BNCH1038-100 100uL
EUR 199
Description: Primary antibody against CD45RA(111-1C5), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL

CD45RA(111-1C5) Antibody

BNCH1038-500 500uL
EUR 544
Description: Primary antibody against CD45RA(111-1C5), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL

CD45RA(111-1C5) Antibody

BNUM1038-50 50uL
EUR 395
Description: Primary antibody against CD45RA(111-1C5), 1mg/mL

pOTB7-CLDN5(111-912bp)

PVT18531 2 ug
EUR 231

Monoclonal CGA / hCG Alpha Antibody (clone ME.111), Clone: ME.111

APG02560G 0.1mg
EUR 484
Description: A Monoclonal antibody against Human CGA / hCG Alpha (clone ME.111). The antibodies are raised in Mouse and are from clone ME.111. This antibody is applicable in WB and IHC-P, E

Zinc Finger Protein 480 (ZNF480) Antibody

20-abx116741
  • EUR 732.00
  • EUR 398.00
  • 150 ul
  • 50 ul

Zinc Finger Protein 480 (ZNF480) Antibody

abx030192-400ul 400 ul
EUR 523

Zinc Finger Protein 480 (ZNF480) Antibody

abx030192-80l 80 µl
EUR 286

Polyclonal TAOK1 / TAO1 Antibody (aa431-480)

AMM08087G 0.05ml
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human TAOK1 / TAO1 (aa431-480). This antibody is tested and proven to work in the following applications:

Myosin Light Chain Kinase (480-501)

H-3554.0500 0.5mg
EUR 273
Description: Sum Formula: C120H209N41O28S2; CAS# [313642-00-1]

Myosin Light Chain Kinase (480-501)

H-3554.1000 1.0mg
EUR 466
Description: Sum Formula: C120H209N41O28S2; CAS# [313642-00-1]

SSEA-1 Antibody (Clone MC-480)

3063-25
EUR 272

amfiSure PCR Premix, 8-Strip 0.2ml tube with Individual attached cap

P0316-480 5X96 rxns
EUR 529

amfiEco PCR Premix

P0702-480 5x96 rxns
EUR 444

amfiRivert 1-Step RT-PCR Premix

R5004-480 5x96 rxns
EUR 928

Recombinant (E.Coli, GST tag) Hepatitis C Virus (HCV) NS5 Genotype-4 

RP-480 100 ug
EUR 286

WST-1 Cell Proliferation Colorimetric Assay Kit

K2021-480 480 assays
EUR 321

TSLP (R127A, R130A) Recombinant Protein

11-480 0.1 mg
EUR 595.25
Description: Thymic stromal lymphopoietin (TSLP) is an epithelial cell-derived cytokine involved in the pathology of inflammatory skin diseases, and is widely expressed by epithelial cells. Human TSLP cDNA encodes a 159 amino acid (aa) residue precursor protein with a 28 aa signal sequence (4, 5). Human TSLP has been shown to developing nondeletional central tolerance, amplifying epithelium-induced class switching, inducing atopic diseases and maintaining intestinal noninflammatory environment. Among diverse cells responding to Human TSLP, CD11c+ dendritic cells are the most obviously characterized target cells.

IL-4 Recombinant Protein

90-480 10 ug
EUR 364.25
Description: Interleukin-4 (IL-4) is a cytokine produced by type 2 helper T cells, the Th2 cells. These cells tends to make a specific set of lymphokines including IL-4, IL-5, IL-6, IL-10, IL-13, IL-3 and GM-CSF and fail to produce IL-2, IFN-gamma, and lymphotoxin (TNF-beta). In addition, mast cells can produce IL-4. IL-4 exerts numerous effects on various hematopoietic cell types. On B cells, IL-4 promotes immunoglobulin class switching to IgE and IgG1 isotypes and upregulates MHC class II and CD23 expression. IL-4 promotes survival, growth and differentiation of both T and B lymphocytes, mast cells and endothelial cells. In addition, IL-4 inhibits the production of TNF, IL-1 and IL-6 by macrophages.

Reg1 alpha Recombinant Protein

91-480 0.05 mg
EUR 542.75
Description: Regenerating Islet-Derived Protein 1- alpha (REG1A) belongs to the Reg family of secreted proteins with a C-type lectic domain. REG1A is highly expressed levels in fetal and infant brains, much lower in adult brains. REG1A promotes the maintenance and growth of pancreatic islet cells and intestinal villi. In addition to, REG1A Might act as an inhibitor of spontaneous calcium carbonate precipitation and be associated with neuronal sprouting in brain, and with brain and pancreas regeneration.

IL-2 R beta Recombinant Protein

92-480 0.05 mg
EUR 684.5
Description: Human IL-2RB, also known asinterleukin-2 receptor subunit beta,is the receptor for interleukin-2. IL2 receptor complex is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2. IL2 receptor complex has three forms with respect to ability to bind IL2. IL-2RB is belonged to a type I membrane protein,and has a 26 residue signal peptide, a 214 residue extracellular region, a 25 residue transmembrane region and a 286 residue cytoplasmic domain. IL-2RB is the subunit critical for receptor-mediated signaling via physically or functionally coupling to other signaling molecules, such as the Jak-STAT and Src-family protein tyrosine kinase although it lacks apparent catalytic motifs.

Transmembrane Protein 111 (TM111) Antibody

abx032614-400ul 400 ul
EUR 523

Transmembrane Protein 111 (TM111) Antibody

abx032614-80l 80 µl
EUR 286

Prepro VIP (111-122) (human)

5-01793 4 x 5mg Ask for price

Prepro VIP (111-122) Peptide

20-abx265194
  • EUR 495.00
  • EUR 815.00
  • EUR 356.00
  • 10 mg
  • 25 mg
  • 5 mg

Recombinant ASFV Ken-111 Protein

VAng-2105Lsx-inquire inquire Ask for price
Description: African swine fever virus (isolate Pig/Kenya/KEN-50/1950) Probable DNA-directed RNA polymerase subunit 1 homolog (Ken-111), partial, recombinant protein from E. coli. (Uniprot ID: P0C989)

Recombinant ASFV Pret-111 Protein

VAng-2401Lsx-inquire inquire Ask for price
Description: African swine fever virus (isolate Tick/South Africa/Pretoriuskop Pr4/1996) Probable DNA-directed RNA polymerase subunit 1 homolog (Pret-111), partial, recombinant protein from E. coli. (Uniprot ID: P0C987)

Recombinant ASFV War-111 Protein

VAng-2507Lsx-inquire inquire Ask for price
Description: African swine fever virus (isolate Warthog/Namibia/Wart80/1980) Probable mRNA-capping enzyme (War-111), partial, recombinant protein from E. coli. (Uniprot ID: P0C994)

Anti-PCDH17 (aa1098-111) antibody

STJ72707 100 µg
EUR 359

Recombinant Rat Akt1 Protein (aa 1-480)

VAng-2932Lsx-1mg 1 mg
EUR 5590
Description: Recombinant Rat Akt1 is expressed in E. coli. (Uniprot ID: P47196)

Recombinant Rat Akt1 Protein (aa 1-480)

VAng-2932Lsx-200g 200 µg
EUR 3363
Description: Recombinant Rat Akt1 is expressed in E. coli. (Uniprot ID: P47196)

Recombinant Rat Akt1 Protein (aa 1-480)

VAng-2932Lsx-50g 50 µg
EUR 2525
Description: Recombinant Rat Akt1 is expressed in E. coli. (Uniprot ID: P47196)

Recombinant Mouse Akt1 Protein (aa 1-480)

VAng-2933Lsx-1mg 1 mg
EUR 5590
Description: Recombinant Mouse Akt1 is expressed in E. coli. (Uniprot ID: P31750)

We detect signatures of positive selection across several genes related to the development and regulation of the forebrain, hormones, and the iguanian lizard dewlap, suggesting molecular changes underlying behavioral adaptations known to reinforce species boundaries were a key component in the diversification of anolelizards.