Comparative Genomics Reveals Accelerated Evolution in Conserved Pathways during the Diversification of Anole Lizards.

Squamates include all lizards and snakes, and display some of the most diverse and extreme morphological adaptations among vertebrates. However, compared with birds and mammals, relatively few resources exist for comparative genomic analyses of squamates, hampering efforts to understand the molecular bases of phenotypic diversification in such a speciose clade.

In particular, the ∼400 species of anolelizard represent an extensive squamate radiation. Here, we sequence and assemble the draft genomes of three anole species-Anolis frenatus, Anolis auratus, and Anolis apletophallus-for comparison with the available reference genome of Anolis carolinensis. Comparative analyses reveal a rapid background rate of molecular evolution consistent with a model of punctuated equilibrium, and strong purifying selection on functional genomic elements in anoles.

We find evidence for accelerated evolution in genes involved in behavior, sensory perception, and reproduction, as well as in genes regulating limb bud development and hindlimb specification. Morphometric analyses of anole fore and hindlimbs corroborated these findings.

SKT siRNA

20-abx933470
  • EUR 551.00
  • EUR 732.00
  • 15 nmol
  • 30 nmol
  • Shipped within 5-10 working days.

SKT (KIAA1217) Antibody

abx234542-100ug 100 ug
EUR 509
  • Shipped within 5-12 working days.

HSP70 ELISA Kit

SKT-105-480 5 plates of 96 wells
EUR 2260
  • HSP70 genes encode abundant heat-inducible 70-kDa HSPs (HSP70s). In most eukaryotes HSP70 genes exist as part of a multigene family. They are found in most cellular compartments of eukaryotes including nuclei, mitochondria, chloroplasts, the endoplas
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Description: Sandwich ELISA kit used for quantitate HSP70 concentration in Cell Lysates, Tissue, Serum, Urine samples from Human, Goat, Dog

HSC70 ELISA Kit

SKT-106-480 5 plates of 96 wells
EUR 2836
  • HSP70 genes encode abundant heat-inducible 70-kDa HSPs (HSP70s). In most eukaryotes HSP70 genes exist as part of a multigene family. They are found in most cellular compartments of eukaryotes including nuclei, mitochondria, chloroplasts, the endoplas
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Description: Sandwich ELISA kit used for quantitate HSC70 concentration in Cell Lysates, Tissue, Serum, Whole Blood samples from Human, Avian

HSP90 alpha ELISA Kit

SKT-107-480 5 plates of 96 wells
EUR 2702
  • HSP90 is a highly conserved and essential stress protein that is expressed in all eukaryotic cells. From a functional perspective, HSP90 participates in the folding, assembly, maturation, and stabilization of specific proteins as an integral componen
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Description: Sandwich ELISA kit used for quantitate HSP90 alpha concentration in Cell Lysates, Tissue, Serum, Whole Blood samples from Human, Goat, Avian

HSP70 ELISA Kit (High-Sensitivity)

SKT-108-480 5 plates of 96 wells
EUR 2702
  • HSP70 genes encode abundant heat-inducible 70-kDa HSPs (HSP70s). In most eukaryotes HSP70 genes exist as part of a multigene family. They are found in most cellular compartments of eukaryotes including nuclei, mitochondria, chloroplasts, the endoplas
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Description: Sandwich ELISA kit used for quantitate HSP70 concentration in Serum, Plasma, Cell Lysates, Tissue samples from Human, Monkey, Dog, Rat, Mouse

HSP27 ELISA Kit

SKT-109-480 5 plates of 96 wells
EUR 2277
  • HSP27s belong to an abundant and ubiquitous family of small heat shock proteins (sHSP). It is an important HSP found in both normal human cells and cancer cells. The basic structure of most sHSPs is a homologous and highly conserved amino acid sequen
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Description: Sandwich ELISA kit used for quantitate HSP27 concentration in Serum, Plasma, Cell Lysates, Tissue samples from Human

HSP60 ELISA Kit

SKT-110-480 5 plates of 96 wells
EUR 2277
  • In both prokaryotic and eukaryotic cells, the misfolding and aggregation of proteins during biogenesis and under conditions of cellular stress are prevented by molecular chaperones. Members of the HSP60 family of heat shock proteins are some of the b
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Description: Sandwich ELISA kit used for quantitate HSP60 concentration in Cell Lysates, Tissue, Serum samples from Human

HSP65 ELISA Kit

SKT-113-480 5 plates of 96 wells
EUR 2478
  • HSP65 is a member of the HSP60 family of heat shock proteins (2, 3). HSP60s are mitochondrial chaperonins that are typically held responsible for the transportation and refolding of proteins from the cytoplasm into the mitochondrial matrix. In additi
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Description: Sandwich ELISA kit used for quantitate M bovis/M tuberculosum HSP65 concentration in human samples in Cell Lysates, Tissue, Serum samples from M bovis, M tuberculosum

Alpha B Crystallin ELISA Kit

SKT-123-480 5 plates of 96 wells
EUR 2836
  • The alpha-crystallins are major water-soluble lens structural proteins of the vertebrate eye that are related to the small heat shock protein family. The alpha-crystallins possess structural and functional similarities with HSP25 and HSP27 (1). Mamma
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Description: Sandwich ELISA kit used for quantitate alpha B crystallin concentration in Cell Lysates, Tissue, Serum samples from Human

HSP70 ELISA Kit (PLANT)

SKT-124-480 5 plates of 96 wells
EUR 2836
  • HSP70 genes encode abundant heat-inducible 70-kDa HSPs (HSP70s). In most eukaryotes HSP70 genes exist as part of a multigene family. They are found in most cellular compartments of eukaryotes including nuclei, mitochondria, chloroplasts, the endoplas
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Description: Sandwich ELISA kit used for quantitate HSP70 concentration in Plant extract, Cell Lysates, Tissue, Serum, Plasma samples from Plant, Human

Nitrotyrosine ELISA Kit

SKT-126-480 5 plates of 96 wells
EUR 1747
  • Nitrotyrosine has been identified as a marker of inflammation and NO production. Nitrotyrosine is formed in presence of the active metabolite NO. Various pathways including the formation of peroxinitrite lead to nitrotyrosine production. Since nitrot
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Description: Competitive ELISA kit used for quantitate Nitrotyrosine in Plasma, Serum, Cell Lysates, Urine samples from all species

Rat GRP78 ELISA Kit

SKT-137-480 5 plates of 96 wells
EUR 2474
  • GRP78 is a ubiquitously expressed, 78-kDa glucose-regulated protein, and is commonly referred to as an immunoglobin chain binding protein (BiP). The BiP proteins are categorized as stress response proteins because they play an important role in the p
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Description: Sandwich ELISA kit used for quantitate GRP78 concentration in rat samples in Tissue samples from Rat

Dibromo-tyrosine ELISA Kit

SKT-140-480 5 plates of 96 wells
EUR 2195
  • Dibromo-tyrosine is produced by the oxidative bromination of tyrosine residues. This reaction occurs via eosinophil peroxidase (EPO), an enzyme released by activated eosinophils. Upon activation of eosinophils, a respiratory burst occurs releasing el
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Description: Competitive ELISA kit used to quantify free and protein-bound 3,5-dibromotyrosine in Plasma, Urine samples from all species

HO-1 ELISA Kit

SKT-111-96 1 plate of 96 wells
EUR 585
  • Heme-oxygenase is a ubiquitous enzyme that catalyzes the initial and rate-limiting steps in heme catabolism yielding equimolar amounts of biliverdin, iron and carbon monoxide. Biliverdin is subsequently converted to bilirubin and the free iron is seq
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Description: Sandwich ELISA kit used for quantitate HO-1 concentration in Cell Lysates, Tissue, Serum, Cyst fluid samples from Human, Rat

Mouse SKT shRNA Plasmid

20-abx980555
  • EUR 801.00
  • EUR 1121.00
  • 150 µg
  • 300 µg
  • Shipped within 15-20 working days.

JW 480

B5556-10 10 mg
EUR 167

JW 480

B5556-25 25 mg
EUR 325

JW 480

B5556-5 5 mg
EUR 110

JW 480

B5556-50 50 mg
EUR 540

Sulforhodamine 101 sulfonyl chloride [Texas Red®] *CAS 82354-19-6*

480 10 mg
EUR 132
  • R-phrase: R20, R21, R22
  • H-Phrase: H303, H313, H333
  • Symbol for dangerous compounds: Xn
  • UNSPEC Code: 12171501

Mouse Sickle tail protein, Skt ELISA KIT

ELI-29595m 96 Tests
EUR 865

Mouse Sickle tail protein (SKT) ELISA Kit

abx389166-96tests 96 tests
EUR 911
  • Shipped within 5-12 working days.

Superior Prime Broth™

111 500 g
EUR 110

Laminin 111

RA22121 100 ul
EUR 435

Human Sickle tail protein homolog, SKT ELISA KIT

ELI-18163h 96 Tests
EUR 824

Handheld Fluorometer 480/530nm

FL480530 1 unit
EUR 1572
Description: Compact handheld fluorometer (exc.480 and em.530nm) for quantitative determination of various analytes in life sciences R&D, food safety and environmental monitoring. Highly sensitive, rapid-reading, reliable and low cost.

Skt ELISA Kit| Mouse Sickle tail protein ELISA Kit

EF014796 96 Tests
EUR 689

Polyclonal ADD3 Antibody (aa431-480)

APR14821G 0.05ml
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human ADD3 (aa431-480). This antibody is tested and proven to work in the following applications:

Anti-DDX41 (aa468-480) antibody

STJ73402 100 µg
EUR 359

CD45RA(111-1C5) Antibody

BNUM1038-50 50uL
EUR 395
Description: Primary antibody against CD45RA(111-1C5), 1mg/mL

CD45RA(111-1C5) Antibody

BNUB1038-100 100uL
EUR 209
Description: Primary antibody against CD45RA(111-1C5), Concentration: 0.2mg/mL

CD45RA(111-1C5) Antibody

BNUB1038-500 500uL
EUR 458
Description: Primary antibody against CD45RA(111-1C5), Concentration: 0.2mg/mL

CD45RA(111-1C5) Antibody

BNC551038-100 100uL
EUR 199
Description: Primary antibody against CD45RA(111-1C5), CF555 conjugate, Concentration: 0.1mg/mL

CD45RA(111-1C5) Antibody

BNC551038-500 500uL
EUR 544
Description: Primary antibody against CD45RA(111-1C5), CF555 conjugate, Concentration: 0.1mg/mL

CD45RA(111-1C5) Antibody

BNC611038-100 100uL
EUR 199
Description: Primary antibody against CD45RA(111-1C5), CF660R conjugate, Concentration: 0.1mg/mL

CD45RA(111-1C5) Antibody

BNC611038-500 500uL
EUR 544
Description: Primary antibody against CD45RA(111-1C5), CF660R conjugate, Concentration: 0.1mg/mL

CD45RA(111-1C5) Antibody

BNC471038-100 100uL
EUR 199
Description: Primary antibody against CD45RA(111-1C5), CF647 conjugate, Concentration: 0.1mg/mL

CD45RA(111-1C5) Antibody

BNC471038-500 500uL
EUR 544
Description: Primary antibody against CD45RA(111-1C5), CF647 conjugate, Concentration: 0.1mg/mL

CD45RA(111-1C5) Antibody

BNC051038-100 100uL
EUR 199
Description: Primary antibody against CD45RA(111-1C5), CF405M conjugate, Concentration: 0.1mg/mL

CD45RA(111-1C5) Antibody

BNC051038-500 500uL
EUR 544
Description: Primary antibody against CD45RA(111-1C5), CF405M conjugate, Concentration: 0.1mg/mL

CD45RA(111-1C5) Antibody

BNC401038-100 100uL
EUR 199
Description: Primary antibody against CD45RA(111-1C5), CF640R conjugate, Concentration: 0.1mg/mL

CD45RA(111-1C5) Antibody

BNC401038-500 500uL
EUR 544
Description: Primary antibody against CD45RA(111-1C5), CF640R conjugate, Concentration: 0.1mg/mL

CD45RA(111-1C5) Antibody

BNC431038-100 100uL
EUR 199
Description: Primary antibody against CD45RA(111-1C5), CF543 conjugate, Concentration: 0.1mg/mL

CD45RA(111-1C5) Antibody

BNC431038-500 500uL
EUR 544
Description: Primary antibody against CD45RA(111-1C5), CF543 conjugate, Concentration: 0.1mg/mL

CD45RA(111-1C5) Antibody

BNC041038-100 100uL
EUR 199
Description: Primary antibody against CD45RA(111-1C5), CF405S conjugate, Concentration: 0.1mg/mL

CD45RA(111-1C5) Antibody

BNC041038-500 500uL
EUR 544
Description: Primary antibody against CD45RA(111-1C5), CF405S conjugate, Concentration: 0.1mg/mL

CD45RA(111-1C5) Antibody

BNC801038-100 100uL
EUR 199
Description: Primary antibody against CD45RA(111-1C5), CF680 conjugate, Concentration: 0.1mg/mL

CD45RA(111-1C5) Antibody

BNC801038-500 500uL
EUR 544
Description: Primary antibody against CD45RA(111-1C5), CF680 conjugate, Concentration: 0.1mg/mL

CD45RA(111-1C5) Antibody

BNCP1038-250 250uL
EUR 383
Description: Primary antibody against CD45RA(111-1C5), PerCP conjugate, Concentration: 0.1mg/mL

CD45RA(111-1C5) Antibody

BNCR1038-250 250uL
EUR 383
Description: Primary antibody against CD45RA(111-1C5), RPE conjugate, Concentration: 0.1mg/mL

CD45RA(111-1C5) Antibody

BNCA1038-250 250uL
EUR 383
Description: Primary antibody against CD45RA(111-1C5), APC conjugate, Concentration: 0.1mg/mL

CD45RA(111-1C5) Antibody

BNCAP1038-100 100uL
EUR 199
Description: Primary antibody against CD45RA(111-1C5), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

CD45RA(111-1C5) Antibody

BNCAP1038-500 500uL
EUR 544
Description: Primary antibody against CD45RA(111-1C5), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

CD45RA(111-1C5) Antibody

BNCB1038-100 100uL
EUR 199
Description: Primary antibody against CD45RA(111-1C5), Biotin conjugate, Concentration: 0.1mg/mL

CD45RA(111-1C5) Antibody

BNCB1038-500 500uL
EUR 544
Description: Primary antibody against CD45RA(111-1C5), Biotin conjugate, Concentration: 0.1mg/mL

CD45RA(111-1C5) Antibody

BNCH1038-100 100uL
EUR 199
Description: Primary antibody against CD45RA(111-1C5), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL

CD45RA(111-1C5) Antibody

BNCH1038-500 500uL
EUR 544
Description: Primary antibody against CD45RA(111-1C5), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL

CD45RA(111-1C5) Antibody

BNC881038-100 100uL
EUR 199
Description: Primary antibody against CD45RA(111-1C5), CF488A conjugate, Concentration: 0.1mg/mL

CD45RA(111-1C5) Antibody

BNC881038-500 500uL
EUR 544
Description: Primary antibody against CD45RA(111-1C5), CF488A conjugate, Concentration: 0.1mg/mL

CD45RA(111-1C5) Antibody

BNC941038-100 100uL
EUR 199
Description: Primary antibody against CD45RA(111-1C5), CF594 conjugate, Concentration: 0.1mg/mL

CD45RA(111-1C5) Antibody

BNC941038-500 500uL
EUR 544
Description: Primary antibody against CD45RA(111-1C5), CF594 conjugate, Concentration: 0.1mg/mL

CD45RA(111-1C5) Antibody

BNC681038-100 100uL
EUR 199
Description: Primary antibody against CD45RA(111-1C5), CF568 conjugate, Concentration: 0.1mg/mL

CD45RA(111-1C5) Antibody

BNC681038-500 500uL
EUR 544
Description: Primary antibody against CD45RA(111-1C5), CF568 conjugate, Concentration: 0.1mg/mL

CD45RA(111-1C5) Antibody

BNC701038-100 100uL
EUR 199
Description: Primary antibody against CD45RA(111-1C5), CF770 conjugate, Concentration: 0.1mg/mL

CD45RA(111-1C5) Antibody

BNC701038-500 500uL
EUR 544
Description: Primary antibody against CD45RA(111-1C5), CF770 conjugate, Concentration: 0.1mg/mL

CD45RA(111-1C5) Antibody

BNC811038-100 100uL
EUR 199
Description: Primary antibody against CD45RA(111-1C5), CF680R conjugate, Concentration: 0.1mg/mL

CD45RA(111-1C5) Antibody

BNC811038-500 500uL
EUR 544
Description: Primary antibody against CD45RA(111-1C5), CF680R conjugate, Concentration: 0.1mg/mL

pOTB7-CLDN5(111-912bp)

PVT18531 2 ug
EUR 231

SSEA-1 Antibody (Clone MC-480)

3063-25
EUR 272

Polyclonal TAOK1 / TAO1 Antibody (aa431-480)

AMM08087G 0.05ml
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human TAOK1 / TAO1 (aa431-480). This antibody is tested and proven to work in the following applications:

Zinc Finger Protein 480 (ZNF480) Antibody

20-abx116741
  • EUR 732.00
  • EUR 398.00
  • 150 ul
  • 50 ul
  • Shipped within 5-10 working days.

Zinc Finger Protein 480 (ZNF480) Antibody

abx030192-400ul 400 ul
EUR 523
  • Shipped within 5-10 working days.

Zinc Finger Protein 480 (ZNF480) Antibody

abx030192-80l 80 µl
EUR 286
  • Shipped within 5-10 working days.

Myosin Light Chain Kinase (480-501)

H-3554.0500 0.5mg
EUR 273
Description: Sum Formula: C120H209N41O28S2; CAS# [313642-00-1]

Myosin Light Chain Kinase (480-501)

H-3554.1000 1.0mg
EUR 466
Description: Sum Formula: C120H209N41O28S2; CAS# [313642-00-1]

Monoclonal CGA / hCG Alpha Antibody (clone ME.111), Clone: ME.111

APG02560G 0.1mg
EUR 484
Description: A Monoclonal antibody against Human CGA / hCG Alpha (clone ME.111). The antibodies are raised in Mouse and are from clone ME.111. This antibody is applicable in WB and IHC-P, E

WST-1 Cell Proliferation Colorimetric Assay Kit

K2021-480 480 assays
EUR 321

amfiSure PCR Premix, 8-Strip 0.2ml tube with Individual attached cap

P0316-480 5X96 rxns
EUR 529

amfiEco PCR Premix

P0702-480 5x96 rxns
EUR 444

amfiRivert 1-Step RT-PCR Premix

R5004-480 5x96 rxns
EUR 928

Recombinant (E.Coli, GST tag) Hepatitis C Virus (HCV) NS5 Genotype-4 

RP-480 100 ug
EUR 286

Prepro VIP (111-122) (human)

5-01793 4 x 5mg Ask for price

Transmembrane Protein 111 (TM111) Antibody

abx032614-400ul 400 ul
EUR 523
  • Shipped within 5-10 working days.

Transmembrane Protein 111 (TM111) Antibody

abx032614-80l 80 µl
EUR 286
  • Shipped within 5-10 working days.

Prepro VIP (111-122) Peptide

20-abx265194
  • EUR 495.00
  • EUR 815.00
  • EUR 356.00
  • 10 mg
  • 25 mg
  • 5 mg
  • Shipped within 5-10 working days.

Anti-PCDH17 (aa1098-111) antibody

STJ72707 100 µg
EUR 359

Recombinant ASFV Ken-111 Protein

VAng-2105Lsx-inquire inquire Ask for price
Description: African swine fever virus (isolate Pig/Kenya/KEN-50/1950) Probable DNA-directed RNA polymerase subunit 1 homolog (Ken-111), partial, recombinant protein from E. coli. (Uniprot ID: P0C989)

Recombinant ASFV Pret-111 Protein

VAng-2401Lsx-inquire inquire Ask for price
Description: African swine fever virus (isolate Tick/South Africa/Pretoriuskop Pr4/1996) Probable DNA-directed RNA polymerase subunit 1 homolog (Pret-111), partial, recombinant protein from E. coli. (Uniprot ID: P0C987)

Recombinant ASFV War-111 Protein

VAng-2507Lsx-inquire inquire Ask for price
Description: African swine fever virus (isolate Warthog/Namibia/Wart80/1980) Probable mRNA-capping enzyme (War-111), partial, recombinant protein from E. coli. (Uniprot ID: P0C994)

Protein-A ELISA Kit, 480 tests, Quantitative

800-110-PRA-5 1 pk
EUR 3095

Mouse Olfactory receptor 480, Olfr480 ELISA KIT

ELI-14769m 96 Tests
EUR 865

Opti-Seal qPCR Roche 480 (Low profile)

G913 100 Plates/Case
EUR 302

Opti-Seal qPCR Roche 480 (Low profile)

G914 10 Plates/Box
EUR 76

Recombinant MARV nifE (aa 1-480) Protein

VAng-Wyb3541-1mgEcoli 1 mg (E. coli)
EUR 5247
Description: Methanothermobacter marburgensis (strain DSM 2133 / 14651 / NBRC 100331 / OCM 82 / Marburg) nitrogenase iron-molybdenum cofactor biosynthesis protein NifE, recombinant protein.

Recombinant MARV nifE (aa 1-480) Protein

VAng-Wyb3541-500gEcoli 500 µg (E. coli)
EUR 3707
Description: Methanothermobacter marburgensis (strain DSM 2133 / 14651 / NBRC 100331 / OCM 82 / Marburg) nitrogenase iron-molybdenum cofactor biosynthesis protein NifE, recombinant protein.

Recombinant MARV nifE (aa 1-480) Protein

VAng-Wyb3541-50gEcoli 50 µg (E. coli)
EUR 2525
Description: Methanothermobacter marburgensis (strain DSM 2133 / 14651 / NBRC 100331 / OCM 82 / Marburg) nitrogenase iron-molybdenum cofactor biosynthesis protein NifE, recombinant protein.

Recombinant Rat Akt1 Protein (aa 1-480)

VAng-2932Lsx-1mg 1 mg
EUR 5590
Description: Recombinant Rat Akt1 is expressed in E. coli. (Uniprot ID: P47196)

We detect signatures of positive selection across several genes related to the development and regulation of the forebrain, hormones, and the iguanian lizard dewlap, suggesting molecular changes underlying behavioral adaptations known to reinforce species boundaries were a key component in the diversification of anolelizards.